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γ-Aminobutyric acid attenuates high-fat diet-induced cerebral oxidative impairment via enhanced synthesis of hippocampal sulfatides

journal contribution
posted on 27.02.2020, 00:00 authored by X Si, Y Jiang, W Shang, G Shui, SM Lam, C Blanchard, Padraig Strappe, Z Zhou
Long-term high-fat diet (HFD) in rats triggered cerebral oxidative stress, reflected by reactive oxygen species accumulation and antioxidant decline in peripheral and cerebral tissues, together with hippocampal lipid disturbance, particularly for triglyceride accumulation and sulfatide deficiency. Hippocampal formation and cerebral cortex also exhibited pathological changes, characterized by neurofibrillary tangle and reduced Nissl bodies. Sulfatides were noted to protect hippocampal neurons from oxidative damage through the clearance of β-amyloid protein, with apolipoprotein E transporting and low-density lipoprotein receptor binding. Delightedly, we found γ-aminobutyric acid (GABA) supplement delivered by rice bran to rats significantly promoted hippocampal sulfatide synthesis and reversed the HFD-induced sulfatide deficiency and oxidative-triggered cerebral impairment. Elevated GABA concentration in hippocampus and the activation of GABA B-type receptors might be the primary contributors. This study demonstrated the potential of GABA-enriched rice bran as a novel dietary supplement to enhance a sulfatide-based therapeutic approach for neurodegenerative diseases in the early stages. © 2018 American Chemical Society.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

67

Issue

4

Start Page

1081

End Page

1091

Number of Pages

11

eISSN

1520-5118

ISSN

0021-8561

Publisher

American Chemical Society

Peer Reviewed

Yes

Open Access

No

Acceptance Date

04/12/2018

External Author Affiliations

Charles Sturt University; Academy of Military Medical Sciences,Tianjin University of Science and Technology; China

Era Eligible

Yes

Journal

Journal of Agricultural and Food Chemistry