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Vitamin D3 supplementation reduces serum markers of bone resorption and muscle damage in female basketball players with vitamin D inadequacy

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Version 2 2024-02-28, 00:09
Version 1 2024-02-27, 06:32
journal contribution
posted on 2024-02-28, 00:09 authored by E Stojanović, V Jakovljević, Aaron ScanlanAaron Scanlan, Vincent DalboVincent Dalbo, D Radovanović
This study aimed to investigate the effect of vitamin D3 supplementation at a dose of 4,000 IU/day for 6 weeks on serum levels of: 25-hydroxyvitamin D [25(OH)D], bone turnover [osteocalcin and carboxy-terminal telopeptides of crosslinks of type I collagen (CTx-I)], and muscle damage [lactate dehydrogenase (LDH) and creatine kinase (CK)] in middle adolescent (15-18 years) and late-adolescent to early adulthood (19-30 years) female basketball players with inadequate vitamin D status. Participants (N=24) were randomly assigned in a double-blind manner into a vitamin D or placebo group. Data were analyzed using separate 2×2x2 mixed ANOVAs with one within-subjects factor (time) and two between-subjects factors (condition and age). When a significant interaction was observed, the intra-group changes were assessed using paired t tests and Hedge's g. Paired t-tests comparing intra-group changes in the vitamin D condition revealed a non-significant large improvement in 25(OH)D (p = 0.06; g = 0.86), non-significant small decreases in CTx-I (p = 0.13; g = −0.22) and CK (p = 0.07; g = −0.26), as well as a significant moderate decrease in LDH (p = 0.004; g = −0.74). Paired t-tests comparing intra-group changes in the placebo condition revealed a significant moderate decline in 25(OH)D (p <0.001; g = −0.77), as well as significant small increases in CTx-I (p = 0.04; g = 0.47) and CK (p = 0.04; g = 0.36). Vitamin D3 supplementation at 4,000 IU/day could be effective in reducing bone resorption and muscle damage in female basketball players with inadequate baseline vitamin D, irrespective of age.

History

Volume

22

Issue

10

Start Page

1532

End Page

1542

Number of Pages

10

eISSN

1536-7290

ISSN

1746-1391

Location

England

Publisher

Wiley

Language

eng

Peer Reviewed

  • Yes

Open Access

  • Yes

Era Eligible

  • Yes

Medium

Print-Electronic

Journal

European Journal of Sport Science

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