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Validation of centrifugation as a countermeasure for otolith deconditioning during spaceflight: Preliminary data of the ESA SPIN study

journal contribution
posted on 19.09.2018, 00:00 by KI Buytaert, HG MacDougall, Steven MooreSteven Moore, G Clement, N Pattyn, PF Migeotte, FL Wuyts
In the framework of further space exploration, countermeasures to combat the drawbacks of human space flights are essential. The present study focuses on the influence of microgravity on the otolith-ocular reflex and aims to test the hypothesis of artificial gravity being an adequate countermeasure for the deconditioning of the aforementioned reflex. The so-called SPIN study, commissioned by the European Space Agency, can be considered as a control experiment in the broad sense for the Neurolab mission (STS-90) during which 4 crewmembers of the space shuttle were subjected to in-flight centrifugation on the visual and vestibular investigation system (VVIS). After their nearly 16-day mission, they did not suffer from orthostatic intolerance and spatial disorientation. In addition, the relevant parameters of the otolith-ocular interaction remained unaffected. For this study cosmonauts from a long duration stay in the International Space Station that were not centrifuged in-flight were tested on the VVIS (1 g centripetal interaural acceleration) on 6 different days. Three measurements were taken about 1.5-2 months prior to launch and 3 were taken at 1, 4 and 9 days after return from space. Ocular counter-rolling was measured before, during and after rotation on the VVIS using infrared video goggles and compared pair wise using Friedman tests. The perception of verticality was monitored using an ultrasound system for perceptual evaluation. The preliminary results of 4 cosmonauts showed a surprisingly large inter-individual variability of the measurements. Although OCR and perception of verticality appeared to be influenced overall by the exposure to microgravity, the wide variability among the cosmonauts obscured any statistical significance, in particular due to one cosmonauts being inconsistent with the other 3. Despite the specificity of the tests under normal conditions, the diverse response to spaceflight of our subjects exposes the complexity of the peripheral and central neural adaptive processes.

History

Volume

23

Issue

1

Start Page

23

End Page

31

Number of Pages

9

eISSN

1878-6464

ISSN

0957-4271

Publisher

IOS Press

Peer Reviewed

Yes

Open Access

No

Acceptance Date

21/09/2012

External Author Affiliations

Antwerp University Research Centre for Equilibrium and Aerospace (AUREA); University of Antwerp; University of Sydney; Royal Military Academy; Mount Sinai School of Medicine

Era Eligible

Yes

Journal

Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science