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Vaccine development against dengue, a viral disease of increasing significance to global public health : editorial

journal contribution
posted on 06.12.2017, 00:00 by Narayan GyawaliNarayan Gyawali, Andrew Taylor-RobinsonAndrew Taylor-Robinson
Dengue is a mosquito-borne viral disease of humans that is a major public health concern in tropical and sub-tropical regions of the world. The increasing mortality and morbidity rates caused by infection in recent years are attributable partly to a lack of availability of effective antiviral therapies and vaccines. In a concerted attempt to arrest this global expansion, several dengue vaccine candidates have progressed from pre-clinical testing into clinical trials. However, the advancement of vaccine development has manifest challenges to be overcome. A principal tenet underpinning dengue vaccine design is balanced immunity to all five recognised virus serotypes, but difficulties in achieving optimal attenuation of each virus and interference between individual attenuated viruses are significant hurdles to successful implementation. Currently, the most advanced vaccine candidate, the recombinant, live-attenuated ChimeriVax-DEN1-4 preparation developed by Sanofi Pasteur, is likely to achieve licensure at the completion of phase III trials and undergo population safety surveillance. Subunit and DNA vaccines are also in various stages of clinical evaluation. The intrinsic rationale is to produce a safe, efficacious and cost-effective vaccine. While this remains an achievable goal, progress is limited by an incomplete understanding of dengue viral pathogenesis, together with a lack of suitable animal models for fundamental pre-clinical development. This editorial highlights current approaches and future directions for vaccine strategies to combat the global expansion of this infectious disease.

History

Volume

2

Issue

a10

Start Page

1

End Page

4

Number of Pages

4

ISSN

2090-0392

Location

Bhadrak,Odisha, India

Publisher

Biohelikon

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

School of Medical and Applied Sciences (2013- ); TBA Research Institute;

Era Eligible

No

Journal

Immunity and diseases.