Using risk and odds ratios to assess effect size for meta-analysis outcome measures

Best practice is built on the principle of aggregating all available evidence on a topic to make a clinical decision on the most appropriate intervention for the situation at hand. Systematic reviews and meta-analyses are powerful tools that summarize the evidence for current best practice guidelines for the available interventions for a particular problem (Moher, Liberati, Tetzlaff, & Altman, 2009). Meta-analysis combines the results of multiple studies to produce an aggregated and more precise estimates of the benefits of the interventions. Meta-analysis of high-quality randomized trials is considered the highest level of evidence to inform practice.