Urease production as a marker of virulence in Pseudomonas aeruginosa

In summary, the findings of this paper show that a urease negative phenotype is a potential marker for attenuated virulence in Pseudomonas aeruginosa isolates. Further investigation, including amplification and sequencing of rpoN, followed by correlation to quantitative measures of urease enzyme production, would determine if absence of urease enzyme expression is consequent on rpoN mutation in isolates of P. aeruginosa.