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Understanding the mechanisms of zinc bacitracin and avilamycin on animal production: Linking gut microbiota and growth performance in chickens

journal contribution
posted on 20.12.2017, 00:00 authored by E Crisol-Martínez, Dragana StanleyDragana Stanley, MS Geier, RJ Hughes, RJ Moore
© 2017, Springer-Verlag Berlin Heidelberg. Unravelling the mechanisms of how antibiotics influence growth performance through changes in gut microbiota can lead to the identification of highly productive microbiota in animal production. Here we investigated the effect of zinc bacitracin and avilamycin on growth performance and caecal microbiota in chickens and analysed associations between individual bacteria and growth performance. Two trials were undertaken; each used 96 individually caged 15-day-old Cobb broilers. Trial 1 had a control group (n = 48) and a zinc bacitracin (50 ppm) treatment group (n = 48). Trial 2 had a control group (n = 48) and an avilamycin (15 ppm) treatment group (n = 48). Chicken growth performance was evaluated over a 10-day period, and caecal microbiota was characterised by sequencing of bacterial 16S rRNA gene amplicons. Avilamycin produced no effect on growth performance and exhibited little significant disturbance of the microbiota structure. However, zinc bacitracin reduced the feed conversion ratio (FCR) in treated birds, changed the composition and increased the diversity of their caecal microbiota by reducing dominant species. Avilamycin only produced minor reductions in the abundance of two microbial taxa, whereas zinc bacitracin produced relatively large shifts in a number of taxa, primarily Lactobacillus species. Also, a number of phylotypes closely related to lactobacilli species were positively or negatively correlated with FCR values, suggesting contrasting effects of Lactobacillus spp. on chicken growth performance. By harnessing such bacteria, it may be possible to develop high-productivity strategies in poultry that rely on the use of probiotics and less on in-feed antibiotics.

Funding

Category 4 - CRC Research Income

History

Volume

101

Issue

11

Start Page

4547

End Page

4559

Number of Pages

14

eISSN

1432-0614

ISSN

0175-7598

Publisher

Springer Verlag

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

University of New England; The University of South Australia; South Australian Research and Development Institute; The University of Adelaide; RMIT University; Monash University

Era Eligible

Yes

Journal

Applied Microbiology and Biotechnology