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The validity of temperature-sensitive ingestible capsules for measuring core body temperature in laboratory protocols

journal contribution
posted on 06.12.2017, 00:00 by David Darwent, Xuan Zhou, C Van den Heuvel, Charli Sargent, Gregory Roach
The human core body temperature (CBT) rhythm is tightly coupled to an endogenous circadian pacemaker located in the suprachiasmatic nucleus of the anterior hypothalamus. The standard method for assessing the status of this pacemaker is by continuous sampling of CBT using rectal thermometry. This research sought to validate the use of ingestible, temperature-sensitive capsules to measure CBT as an alternative to rectal thermometry. Participants were 11 young adult males who had volunteered to complete a laboratory protocol that extended across 12 consecutive days. A total of 87 functional capsules were ingested and eliminated by participants during the laboratoryinternment. Core body temperature samples were collected in 1-min epochs and compared to paired samples collected concurrently via rectal thermistors. Agreement between samples that were collected using ingestible sensors and rectal thermistors was assessed using the gold-standard limits of agreement method. Across all valid paired samples collected during the study (n = 120,126), the mean difference was 0.06°C, whereas the 95% CI (confidence interval) for differences was less than ±0.35°C. Despite the overall acceptable limits of agreement, systematic measurement bias was noted across the initial 5 h of sensor-transit periods and attributed to temperature gradations across the alimentary canal.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

288

Start Page

719

End Page

726

Number of Pages

8

eISSN

1525-6073

ISSN

0742-0528

Location

United Kingdom

Publisher

Informa Healthcare

Language

en-aus

Peer Reviewed

Yes

Open Access

No

Era Eligible

Yes

Journal

Chronobiology international : the journal of biological and medical rhythm research.

Exports