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The role of MTHFR polymorphisms in the risk of lipedema

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posted on 2023-05-30, 02:10 authored by P Gualtieri, M Al-Wadart, GL De Santis, N Alwadart, D Della Morte, Chantelle ClarkeChantelle Clarke, Talitha BestTalitha Best, C Salimei, G Bigioni, R Cianci, A De Lorenzo, L Di Renzo
OBJECTIVE: This study examines the role of MTHFR gene polymorphism (rs1801133) in women with lipedema (LIPPY) body composition parameters compared to a control group (CTRL). SUBJECTS AND METHODS: We carried out a study on a sample of 45 LIPPY and 50 women as a CTRL. Body composition parameters were examined by Dual-energy X-ray Absorptiometry (DXA). A genetic test was performed for the MTHFR polymorphism (rs1801133, 677C>T) using a saliva sample for LIPPY and CTRL groups. Mann-Whitney tests evaluated statistically significant differences between four groups (carriers and non-carriers of the MTHFR polymorphism for LIPPY and CTRL groups) on anthropometric/body composition parameters to identify patterns. RESULTS: LIPPY showed significantly higher (p<0.05) anthropometric parameters (weight, BMI, waist, abdominal, hip circumferences) and lower waist/hip ratio (p<0.05) compared to the CTRL group. The association between the polymorphism alleles related to the rs1801133 MTHFR gene and the body composition values LIPPY carriers (+) showed an increase in fat tissue of legs and fat region of legs percentage, arm’s fat mass (g), leg’s fat mass (g), and leg’s lean mass (g) (p<0.05) compared to CTRL (+). Lean/fat arms and lean/fat legs were lower (p<0.05) in LIPPY (+) than in CTRL (+). In the LIPPY (+), the risk of developing the lipedema disease was 2.85 times higher (OR=2.85; p<0.05; 95% confidence interval = 0.842-8.625) with respect to LIPPY (-) and CTRL. CONCLUSIONS: The presence or absence of MTHFR polymorphism offers predictive parameters that could better characterize women with lipedema based on the association between body composition and MTHFR presence.

History

Volume

27

Issue

4

Start Page

1625

End Page

1632

Number of Pages

8

eISSN

2284-0729

ISSN

1128-3602

Publisher

Verduci Editore srl

Additional Rights

CC BY-NC-ND 4.0

Language

eng

Peer Reviewed

  • Yes

Open Access

  • Yes

External Author Affiliations

Jordan University of Science and Technology, Jerash University, Jordan; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario “A. Gemelli”, University of Rome “La Sapienza”, San Raffaele Roma Open University, University of Tor Vergata, Italy

Author Research Institute

  • Appleton Institute

Era Eligible

  • Yes

Medium

Print

Journal

European review for medical and pharmacological sciences

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