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The relative contributions of the homeostatic and circadian processes to sleep regulation under conditions of severe sleep restriction

journal contribution
posted on 06.12.2017, 00:00 by G Paech, Sally Ferguson, Charli Sargent, D Kennaway, Gregory Roach
Study Objectives: To investigate the relative contributions of the homeostatic and circadian processes on sleep regulation under conditions of severe sleep restriction. Design: The 13-day laboratory based study consisted of 3 x 24-h baseline days (8 h sleep opportunity, 16 h wake) followed by 7 x 28-h forced desynchrony days (4.7 h sleep opportunity, 23.3 h wake). Setting: The study was conducted in a time isolation unit at the Centre for Sleep Research, University of Australia. Participants: Fourteen healthy, nonsmoking males, aged 21.8 SD) years participated in the study. Interventions N/AMeasurements: Sleep was measured using standard polysomnography. Core body temperature (CBT) was recorded and continuously using a rectal termistor. Each epoch of sleep was assigned a circadian phase based on the CBT data (6 x 60-degree bins) and an elapsed time into sleep episode (2 x 140-min intervals). Results: The percentage of SWS decreased with elapsed time into the sleep episode. However, no change in the percentage of REM sleep was observed with sleep progression. Whilst there was a circadian modulation of REM sleep, the amplitude of the circadian variation was smaller than expected. Sleep efficiency remained high throughout the sleep episode and across all circadian phases.Conclusions: Previous forced desynchrony studies have demonstrated a strong circadian influence on sleep, in the absence of sleep restriction. The current study suggests that in the presence of high homeostatic pressure, the circadian modulation of sleep, in particular sleep efficiency and to a lesser extent, REM sleep, are reduced.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

35

Issue

7

Start Page

941

End Page

948

Number of Pages

8

eISSN

1550-9109

ISSN

0161-8105

Location

United States

Publisher

Associated Professional Sleep Societies

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Appleton Institute for Behavioural Sciences; Appleton Institute for Behavioural Sciences; Centre for Sleep Research; Robinson Institute;

Era Eligible

Yes

Journal

Sleep.

Exports