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The oncogenic role of miR-155 in breast cancer

journal contribution
posted on 21.11.2018, 00:00 authored by S Mattiske, RJ Suetani, Paul NeilsenPaul Neilsen, DF Callen
miR-155 is an oncogenic miRNA with well described roles in leukemia. However, additional roles of miR-155 in breast cancer progression have recently been described. A thorough literature search was conducted to review all published data to date, examining the role of miR-155 in breast cancer. Data on all validated miR-155 target genes was collated to identify biologic pathways relevant to miR-155 and breast cancer progression. Publications describing the clinical relevance, functional characterization, and regulation of expression of miR-155 in the context of breast cancer are reviewed. A total of 147 validated miR- 155 target genes were identified from the literature. Pathway analysis of these genes identified likely roles in apoptosis, differentiation, angiogenesis, proliferation, and epithelial-mesenchymal transition. The large number of validated miR-155 targets presented here provide many avenues of interest as to the clinical potential of miR-155. Further investigation of these target genes will be required to elucidate the specific mechanisms and functions of miR-155 in breast cancer. This is the first review examining the role of miR- 155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA. ©2012 AACR.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

21

Issue

8

Start Page

1236

End Page

1243

Number of Pages

9

ISSN

1055-9965

Publisher

American Association for Cancer Research

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

University of Adelaide

Era Eligible

Yes

Journal

Cancer Epidemiology Biomarkers and Prevention