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The impact of oral probiotics on vaginal Group B Streptococcal colonisation rates in pregnant women: A pilot randomised control study

journal contribution
posted on 29.08.2018, 00:00 by P Olsen, Moira WilliamsonMoira Williamson, V Traynor, C Georgiou
Objective: To perform a pilot project to determine if this research design was appropriate to explore potential causal relationships between oral probiotic use and vaginal Group B Streptococcal (GBS) colonisation rates in pregnant women. Method: Thirty-four GBS-positive women at 36 weeks pregnant were recruited. The participants were randomly allocated to the control group, who received standard antenatal care, or to the intervention group, who received standard antenatal care and a daily oral dose of probiotics for three weeks or until they gave birth. A vaginal GBS swab was collected three weeks post consent or during labour. Findings: No significant difference was found in vaginal GBS rates between the control and intervention groups. Only seven of 21 women in the intervention group completed the entire 21 days of probiotics. A subgroup analysis, including only those who had completed 14 days or more of probiotics (n = 16), also showed no significant difference in vaginal GBS when compared to the control. The findings did show significantly more vaginal commensals in the probiotics group (p = 0.048). Discussion: Five possible reasons for the lack of significant results are: the length of the intervention was too short; the dosage of the probiotics was too low; the wrong strains of probiotics were used; the sample size was inadequate; or oral probiotics are ineffective in impacting vaginal GBS. Implications: The finding of a significant increase of vaginal commensals in women who completed 14 days or more of probiotics supports the potential of probiotics to impact vaginal GBS in pregnancy. © 2017 Australian College of Midwives

History

Volume

31

Issue

1

Start Page

31

End Page

37

Number of Pages

7

eISSN

1878-1799

ISSN

1871-5192

Publisher

Elsevier, Netherlands

Additional Rights

the journal offers authors the option of making their article freely available to all via the ScienceDirect platform

Peer Reviewed

Yes

Open Access

Yes

Acceptance Date

06/06/2017

External Author Affiliations

Monash University; Eastern Health, Box Hill, Victoria; The Sutherland Hospital, Caringbah, NSW; University of Wollongong

Era Eligible

Yes

Journal

Women and Birth