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The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

journal contribution
posted on 05.05.2021, 02:15 by Severine Lamon, Aimee Morabito, Emily Arentson-Lantz, Olivia Knowles, Grace VincentGrace Vincent, Dominique Condo, Sarah E Alexander, Andrew Garnham, Douglas Paddon-Jones, Brad Aisbett
Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society Chronic sleep loss is a potent catabolic stressor, increasing the risk of metabolic dysfunction and loss of muscle mass and function. To provide mechanistic insight into these clinical outcomes, we sought to determine if acute sleep deprivation blunts skeletal muscle protein synthesis and promotes a catabolic environment. Healthy young adults (N = 13; seven male, six female) were subjected to one night of total sleep deprivation (DEP) and normal sleep (CON) in a randomized cross-over design. Anabolic and catabolic hormonal profiles were assessed across the following day. Postprandial muscle protein fractional synthesis rate (FSR) was assessed between 13:00 and 15:00 and gene markers of muscle protein degradation were assessed at 13:00. Acute sleep deprivation reduced muscle protein synthesis by 18% (CON: 0.072 ± 0.015% vs. DEP: 0.059 ± 0.014%·h-1, p =.040). In addition, sleep deprivation increased plasma cortisol by 21% (p =.030) and decreased plasma testosterone by 24% (p =.029). No difference was found in the markers of protein degradation. A single night of total sleep deprivation is sufficient to induce anabolic resistance and a procatabolic environment. These acute changes may represent mechanistic precursors driving the metabolic dysfunction and body composition changes associated with chronic sleep deprivation.

History

Volume

9

Issue

1

Start Page

1

End Page

13

Number of Pages

13

eISSN

2051-817X

ISSN

2051-817X

Location

United States

Publisher

Wiley Open Access

Publisher License

CC BY

Additional Rights

CC BY 4.0

Language

eng

Peer Reviewed

Yes

Open Access

Yes

Acceptance Date

08/11/2020

External Author Affiliations

Deakin University

Author Research Institute

Appleton Institute

Era Eligible

Yes

Medium

Print

Journal

Physiological Reports

Article Number

e14660