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The effect of Leptospermum petersonii essential oil on Candida albicans and Aspergillus fumigatus

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posted on 2017-12-06, 00:00 authored by J Hood, Deborah BurtonDeborah Burton, J Wilkinson, H Cavanagh
A variety of assays were utilised to determine the effect of L. petersonii essential oil on both Candida albicans and Aspergillus fumigatus. Hyphal morphology, susceptibility of spheroplasts and uptake of propidium iodide following exposure to the oil suggest that the mode of action of L. petersonii essential oil is through direct disturbance of the fungal cell membrane. Data also confirms that the volatile component of the oil is highly antifungal, independent of direct contact between the liquid oil and the fungal membrane. The degree of inhibition was greater when fungi were directly exposed to oil volatiles compared to pre-inoculation exposure of oil volatiles into the agar. It is likely that the essential oil volatiles are acting both directly and indirectly on the fungi to produce growth inhibition.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

48

Issue

7

Start Page

922

End Page

931

Number of Pages

10

eISSN

1460-2709

ISSN

1369-3786

Location

London, England

Publisher

Informa Healthcare

Language

en-aus

Peer Reviewed

  • Yes

Open Access

  • No

External Author Affiliations

Dept. of Health and Ageing; Office of Health Protection; School of Biomedical Sciences; Surveillance Branch;

Era Eligible

  • Yes

Journal

Medical mycology.

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