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Temporal characteristics of high-frequency lower-limb oscillation during freezing of gait in Parkinson's disease

journal contribution
posted on 04.09.2018, 00:00 by DA Yungher, TR Morris, V Dilda, JM Shine, SL Naismith, SJG Lewis, Steven MooreSteven Moore
A cardinal feature of freezing of gait (FOG) is high frequency (3-8 Hz) oscillation of the legs, and this study aimed to quantify the temporal pattern of lower-body motion prior to and during FOG. Acceleration data was obtained from sensors attached to the back, thighs, shanks, and feet in 14 Parkinson's disease patients performing timed-up-and-go tasks, and clinical assessment of FOG was performed by two experienced raters from video. A total of 23 isolated FOG events, defined as occurring at least 5 s after gait initiation and with no preceding FOG, were identified from the clinical ratings. The corresponding accelerometer records were analyzed within a 4 s window centered at the clinical onset of freezing. FOG-related high-frequency oscillation (an increase in power in the 3-8 Hz band >3 SD from baseline) followed a distal to proximal onset pattern, appearing at the feet, shanks, thighs, and then back over a period of 250 ms. Peak power tended to decrease as the focus of oscillation moved from feet to back. There was a consistent delay (mean 872 ms) between the onset of high frequency oscillation at the feet and clinical onset of FOG. We infer that FOG is characterized by high frequency oscillation at the feet, which progresses proximally and is mechanically damped at the torso. © 2014 Don A. Yungher et al.

Funding

Other

History

Volume

2014

Start Page

1

End Page

8

Number of Pages

8

eISSN

2042-0080

ISSN

2090-8083

Publisher

Hindawi

Additional Rights

CC BY 3.0

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

Mount Sinai School of Medicine; University of Sydney;

Era Eligible

Yes

Journal

Parkinson's Disease

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