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Synthesis of bis-peptides attached on poly[n]norbornene molecular scaffolds with well-defined relative positions and distances

journal contribution
posted on 06.12.2017, 00:00 by M Shang, Ronald WarrenerRonald Warrener, Douglas ButlerDouglas Butler, Y Murata, D Margetic
This article describes novel synthetic approaches to polynorbornene molecular scaffolds substituted with peptides at various, well-defined positions. A library of norbornene building blocks with attached peptides was prepared. Alkene cyclobutane epoxide (ACE) coupling method was used as a key step reaction for the connection of two norbornene building blocks into bis-peptide scaffolds. Photodimerization of cyclobutene diesters offers an alternative route to polynorbornene bis-peptides. Pyrrolo-peptides were used for preparation of peptide-substituted 7-aza norbornenes. Asymmetrical bis-peptide scaffolds were prepared by ACE coupling of peptide-norbornane epoxide with another norbornene-peptide block. Chemical elaboration of bridgehead dimethyl esters of ACE products or epoxide ACE reagents was also used for peptide attachment.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

15

Issue

2

Start Page

541

End Page

560

Number of Pages

20

ISSN

1381-1991

Location

Netherlands

Publisher

Springer Science+Business Media

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Centre for Molecular Architecture; Institut Ruđer Bos̆ković; Kyōto Daigaku; TBA Research Institute;

Era Eligible

Yes

Journal

Molecular diversity.

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