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Studies on the unique properties of resistant starch and chito-oligosaccharide complexes for reducing high-fat diet-induced obesity and dyslipidemia in rats

journal contribution
posted on 28.05.2018, 00:00 by W Shang, X Si, Z Zhou, J Wang, Padraig Strappe, C Blanchard
Anti-obesity effect of chito-oligosaccharides (CO), resistant starch (RS) and their complexes (CO-RS) was investigated using high-fat fed rats. All of three intervention groups showed anti-obesity effect in the following order: CO-RS > CO > RS. This study revealed CO-RS administration achieved the lightest body weight, the lowest liver weight/index and the highest level of total antioxidant capacity in serum. The RNA sequencing data indicated that peroxisome proliferator-activated receptor (PPAR) pathway was significantly enriched by CO-RS administration. Among the genes involved in PPAR pathway, changes in the expression of Cyp7a1 gene were noticed, indicating an accelerated conversion of cholesterol into bile acids. Furthermore, the current study also revealed that, compared to the high-fat diet control, intervention with CO-RS led to significant reduction in mRNA expression of insulin-induced genes (Insig-1), which did not occur in other two interventions, suggesting a different regulatory pathway affecting lipids metabolism compared with either CO or RS. © 2017 Elsevier Ltd

Funding

Other

History

Volume

38, Part A

Start Page

20

End Page

27

Number of Pages

8

ISSN

1756-4646

Publisher

Elsevier, Netherlands

Peer Reviewed

Yes

Open Access

No

Acceptance Date

17/08/2017

External Author Affiliations

Tianjin University of Science and Technology, Tianjin 300457, China; Charles Sturt University

Era Eligible

Yes

Journal

Journal of Functional Foods

Exports