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Splice variants of the Alzheimer's disease beta-secretase, BACE1

journal contribution
posted on 13.09.2018, 00:00 by RMD Holsinger, N Goense, J Bohorquez, Padraig Strappe
Cleavage of the amyloid precursor protein by enzymes commonly referred to as β- and γ-secretase constitute an important process in the pathogenesis of Alzheimer's disease (AD). The regulation of this process is therefore an important subject of investigation. Numerous sources of endogenous regulation have been identified, and one of these is the relative abundance and regulation of splice variants of the β-secretase, BACE1 (β-site amyloid precursor protein cleaving enzyme 1). In this review, we will briefly discuss the main characteristics of BACE1, review the different variants of this enzyme that have been identified to date, and highlight their possible implication in AD. © 2012 Springer-Verlag Berlin Heidelberg.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

14

Issue

1

Start Page

1

End Page

9

Number of Pages

9

eISSN

1364-6753

ISSN

1364-6745

Publisher

Springer, Germany

Peer Reviewed

Yes

Open Access

No

Acceptance Date

15/10/2012

External Author Affiliations

The University of Sydney

Era Eligible

Yes

Journal

Neurogenetics

Exports