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Sleep–wake disturbances in common neurodegenerative diseases : a closer look at selected aspects of the neural circuitry

journal contribution
posted on 06.12.2017, 00:00 by G Zhong, S Naismith, Naomi Rogers, S Lewis
There is a growing appreciation regarding the relationship between common neurodegenerative diseases, such as Alzheimer's and Parkinson's and sleep–wake disturbances. These clinical features often herald the onset of such conditions and certainly appear to influence disease phenotype and progression. This article reviews some of the pathophysiological processes underlying specific disruptions within the neural circuitry underlying sleep–wake disturbances and explores how clinicopathological relationships commonly manifest. It is proposed that a greater understanding of these relationships should allow insights in to the efficacy of currently available treatments and help in the development of future therapies targeting disruptions within the sleep–wake neural circuitry.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

307

Issue

1-2

Start Page

9

End Page

14

Number of Pages

6

eISSN

1878-5883

ISSN

0022-510X

Location

Netherlands

Publisher

Elsevier

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Brain and Mind Research Institute; Faculty of Arts, Business, Informatics and Education; TBA Research Institute;

Era Eligible

Yes

Journal

Journal of the neurological sciences.

Exports