File(s) not publicly available

Sleep and circadian disruption and the gut microbiome-possible links to dysregulated metabolism

journal contribution
posted on 27.08.2021, 01:55 by Dana Withrow, Samuel J Bowers, Christopher M Depner, Antonio González, Amy ReynoldsAmy Reynolds, Kenneth P Wright
Insufficient sleep and circadian misalignment are associated with adverse metabolic health outcomes. Alterations in gut microbial diversity occur with insufficient sleep and circadian misalignment, which can lead to modifications in microbial structure and function. Changes in microbially produced and modified metabolites such as short chain fatty acids and secondary bile acids may contribute to chronic inflammation, positive energy balance and endocrine changes, and represent potential mechanisms linking insufficient sleep and circadian misalignment with metabolic dysregulation. Literature primarily from the last two years is reviewed here, examining the impact of sleep and circadian rhythms and their disruption on the gut microbiome in human and non-human models, with an emphasis on the hypothesis that the altered gut microbiome may be one pathway by which insufficient sleep and circadian misalignment dysregulate metabolism.

History

Volume

17

Start Page

26

End Page

37

Number of Pages

12

eISSN

2451-9650

ISSN

2451-9650

Publisher

Elsevier

Language

en

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

University of Colorado-Boulder; Northwestern University; University of Utah; University of California at San Diego, USA

Author Research Institute

Appleton Institute

Era Eligible

Yes

Journal

Current Opinion in Endocrine and Metabolic Research