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Risk factors for intensive care in children with acute asthma

journal contribution
posted on 06.12.2017, 00:00 by P Lyell, E Villanueva, Deborah Burton, N Freezer, P Bardin
A retrospective case–control study at Monash Medical Centre (MMC), a tertiary referral hospital in Melbourne, Australia, was conducted to identify risk factors associated with very severe asthma in paediatric patients. Methodology: Asthmatics admitted to an intensive care unit (ICU; n = 52) were identified and considered to represent cases of very severe/near fatal asthma (NFA group). This group was compared to asthmatics who had been admitted on one occasion only to the emergency department at MMC (non-NFA controls, n = 53). Patient files were examined and factors that may be linked to NFA were recorded. Information not on file was obtained from patients/parents during a structured telephone interview. Data for the two groups were compared, univariate and multivariate logistic regression analyses were performed, and odds ratios (OR) were calculated. Results: Univariate analysis indicated that asthmatics with NFA were more likely to be older (P = 0.01) and have a longer duration of asthma (P = 0.02). They were also more likely to have hay fever (P = 0.002; OR, 7.6), use inhaled corticosteroids (P = 0.001), long acting ß2agonists (P = 0.02), have an asthma management plan (P=0.006), and see a respiratory specialist (P = 0.001). Parental smoking habits were not different between the groups. Multivariate logistic regression analysis identified male gender (P = 0.05; OR, 5.7) and use of inhaled corticosteroids (P = 0.07; OR, 7.2) as factors that may be predictive of NFA. Conclusions: This study identifies a number of factors associated with NFA; many are similar to those reported in adult patients. Asthma severity explains some findings, but the data also suggest that additional independent risk factors such as gender and duration of asthma may operate in children.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

10

Start Page

436

End Page

441

Number of Pages

6

eISSN

1440-1843

ISSN

1323-7799

Location

Australia

Publisher

Wiley-Blackwell Publishing Asia

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Charles Sturt University; Monash Institute of Health Services Research; Monash Medical Centre;

Era Eligible

Yes

Journal

Respirology.

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