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Receptor mediated targeting of M-cells
journal contributionposted on 2017-12-06, 00:00 authored by P Tyrer, Jennelle KydJennelle Kyd, A Cripps, A Foxwell, D Otczyk
The intestinal epithelium is a complex system of highly specialised cells that provide digestive and absorptive functions as well as innate and adaptive immunity. Induction of an adaptive immune response in the intestine can occur through the interaction of antigen with M-cells that overlay the lymphoid aggregates of the intestine (Peyer's patches). This study demonstrated that specific common microbial pathogen-associated molecular patterns are recognised by pattern recognition receptors on the surface of the M-cells and this interaction initiates transcytosis through the M-cell of particulate antigen from the intestinal milieu to underlying antigen presenting cells within the Peyer's patch. The study has found that among the pattern recognition molecules that have a role in recognising bacterial components, the apical expression of α5β1 integrin was important for the transcytotic function of M-cells. A proportion of intestinal enterocytes transform to an M-cell morphology in vitro, when cultured with Peyer's patch cells and our studies have demonstrated that CD4+ cells are integral for the development of M-cells in vitro.
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
Number of Pages6
External Author AffiliationsCanberra Hospital; Division of Health, Design and Science; Faculty of Sciences, Engineering and Health; Griffith University;