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Pulmonary immunity to Pseudomonas aeruginosa

journal contribution
posted on 06.12.2017, 00:00 by A Cripps, M Dunkley, R Clancy, Jennelle Kyd
Pseudomonas aeruginosa, an opportunistic bacterial pathogen, is a major course of morbidity and mortality in subjects with compromised respiratory function despite the significant advances in therapeutic practices. The bacteria produces an armoury of products which modify its infective niche to ensure bacterial survival. The role of antibody in protection against pulmonary infection remains poorly defined. Protection appears to be associated with opsonizing antibody whilst some other antibody responses may be deleterious and promote further lung damage. Cell mediated responses are clearly important in protection against infection. This review proposes a vaccine strategy aimed at enhancing specific T cell responses in the lung which, through T cell-derived cytokines, drive the recruitment of neutrophils to the lung and the subsequent activation of these cells results in the clearance of bacteria from the lung.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

73

Start Page

418

End Page

424

Number of Pages

7

eISSN

1440-1711

ISSN

0818-9641

Location

United Kingdom

Publisher

Nature Publishing Group

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Australian Institute of Muscosal lmmunology; University of Canberra; University of Newcastle;

Era Eligible

No

Journal

Immunology and cell biology.

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