Pseudomonas aeruginosa : the potential to immunise against infection
journal contribution
posted on 2017-12-06, 00:00 authored by E Sedlak-Weinstein, Jennelle KydJennelle Kyd, A Cripps, A FoxwellPseudomonas aeruginosa remains a serious pathogen for specific cohorts of patients where chronic infection is a poor prognostic indicator, such as those with cystic fibrosis, burn wounds or those who are immunocompromised. Significant disease burden is associated with a diverse spectrum of both nosocomial and community-acquired infections. To date, vaccines against P. aeruginosa have shown limited and often conflicting efficacy data, especially against heterologous strains, which are increasingly identified as co-colonisers of biofilms. While few studies have gone beyond Phase II clinical trials, a particular concern is the ability of P. aeruginosa to evade the immune system while provoking an immune response that contributes to the destructive nature of infection. Therefore, vaccine development needs to focus on preventing attachment and colonisation, as well as preventing conversion to a mucoid phenotype that is characteristic of the chronic condition that promotes pathology.
History
Volume
5Issue
7Start Page
967End Page
982Number of Pages
16ISSN
1471-2598Location
United KingdomPublisher
Ashley PublicationsPublisher DOI
Full Text URL
Language
en-ausPeer Reviewed
- Yes
Open Access
- No
Era Eligible
- Yes