Three peanut genotypes were cultivated under ambient and elevated CO2 conditions. Elevated CO2 treatment was associated with higher total phenolic content (TPC) values in the shoots and roots of all genotypes. Seeds showed lower levels of TPC compared to the other plant tissue, showing a decline in all three genotypes, and no differences between the CO2 treatments were observed. The Crude Protein (CP) content in seeds varied significantly among the genotypes, and elevated CO2 treatment was associated with mild increases (not significant) in CP of 4 and 6% in Holt and Alloway cultivars, respectively. It is worth mentioning that Kairi contained the highest CP content under elevated CO2 (29%).