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Polyphenols from Australian-grown pigmented red and purple rice inhibit adipocyte differentiation
journal contribution
posted on 2019-03-25, 00:00 authored by ET Callcott, AB Santhakumar, Padraig Strappe, J Luo, CL BlanchardColoured rice is rich in polyphenols and has been shown to have significant antioxidant and anti-adipogenic potential. The study aimed to investigate the anti-adipogenic properties of polyphenol extract (PE) derived from Australian-grown rice varieties. Eight wholegrain pigmented rice varieties were screened for their polyphenol content and antioxidant activity, of which, Yunlu29 (red), Purple (purple) and Reiziq (brown) had the highest values. The selected varieties were then subjected to in-vitro investigation to determine the effect of rice-derived PE on adipocyte differentiation. Lipid accumulation and peroxisome proliferator-activated receptor gamma (PPARγ) expression were quantified by oil red O staining and RT-PCR respectively. PE from Yunlu29 (red) and Purple rice varieties significantly reduced (p < 0.001) lipid accumulation by 53% and 56% respectively and PPARγ expression in adipocytes by 61.2% and 35.6% respectively. PE from Reiziq (brown), did not inhibit lipid accumulation in adipocytes however, did reduce PPARγ expression (p < 0.001). © 2018 Elsevier Ltd
Funding
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
History
Volume
81Start Page
140End Page
146Number of Pages
7eISSN
1095-9963ISSN
0733-5210Publisher
Academic Press, UKPublisher DOI
Peer Reviewed
- Yes
Open Access
- No
Acceptance Date
2018-04-29External Author Affiliations
Charles Sturt University; anco Agricultural Institute, NSWEra Eligible
- Yes
Journal
Journal of Cereal ScienceUsage metrics
Keywords
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