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Phytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementation

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posted on 2024-04-15, 00:45 authored by Sung YuSung Yu, Yadav Sharma BajagaiYadav Sharma Bajagai, Friedrich PetranyiFriedrich Petranyi, S de las Heras-Saldana, Thi Van, Dragana StanleyDragana Stanley
Poultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures and continual vigilance in monitoring animal health parameters. Despite this vigilance, dealing with disease outbreaks is a part of farmers’ routines. Phytogenic feed additives comprised of herbs, spices, essential oils, and oleoresins have potent antimicrobial and anti-inflammatory actions. Related studies are gaining substantial interest in human and animal health worldwide. In this study, a commercial blend phytogenic feed additive was supplemented to layers in an industrial free-range production system with 20,000 birds in both control and treatment groups. At the end of the trial, the ileum tissue was sampled for RNAseq transcriptomic analysis to study the host reaction to the supplement. Phytogenic supplement significantly inhibited four cholesterol-related pathways and reduced the Arteriosclerosis disease category towards improved cardiovascular health. The supplemented birds exhibited reduced disease susceptibility for 26 cancer categories with p-values in the range from 5.23 × 10−4 to 1.02 × 10−25. Major metabolic shifts in Lipid metabolism in combination with Carbohydrate metabolism have resulted in a decrease in the Obesity category, altering the ratio of fat and carbohydrate metabolism toward lower fat storage.

Funding

Category 3 - Industry and Other Research Income

History

Volume

11

Issue

10

Start Page

1

End Page

14

Number of Pages

14

eISSN

2079-6382

ISSN

2079-6382

Publisher

MDPI AG

Publisher License

CC BY

Additional Rights

CC BY

Language

en

Peer Reviewed

  • Yes

Open Access

  • Yes

Acceptance Date

2022-10-14

Author Research Institute

  • Institute for Future Farming Systems

Era Eligible

  • Yes

Medium

Electronic

Journal

Antibiotics

Article Number

ARTN 1428

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