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Phenotyping of leukocytes in the lungs of potoroid marsupials

journal contribution
posted on 06.12.2017, 00:00 by Lauren Young
In this study, T and B lymphocytes were identified in the lungs of two potoroid marsupial species, the endangered Long-footed Potoroo (Potorous longipes) and the Long-nosed Potoroo (Potorous tridactylus). Using species cross-reactive antibodies, plasma cells, B cells and T cells were located in the alveolar septae and lymphocyte clusters were found adjacent to blood vessels and bronchioles. Bronchus-associated lymphoid tissue (BALT), resembling that of other mammals, was present within the bronchiolovascular bundles. Macrophages were occasionally visible in the alveoli, and areas of necrotic tissue in the Long-footed Potoroo contained collections of phagocytic cells, presumably macrophages, which contained acid-fast material and unidentifiable debris. This is the first report of BALT in Potoroo species and an important application of the only available antibodies that can reliably identify lymphocytes in marsupial species.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

21

Issue

1

Start Page

9

End Page

14

Number of Pages

6

eISSN

1618-565X

ISSN

1618-5641

Location

UK

Publisher

Springer UK

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Centre for Environmental Management; Institute for Resource Industries and Sustainability (IRIS);

Era Eligible

Yes

Journal

Comparative clinical pathology.

Exports

CQUniversity

Exports