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Open versus closed systems for vitrification of human oocytes and embryos

journal contribution
posted on 2017-12-06, 00:00 authored by Gabor Vajta, L Rienzi, F Ubaldi
Vitrification is now the dominant approach for cryopreservation of human oocytes and embryos; however, serious disagreement persists, particularly about biosafety issues. Techniques are categorized as either ‘open’ or ‘closed’ according to occurrence of direct contact between the medium and liquid nitrogen during cryopreservation. Advocates of closed systems emphasize the potential danger of disease transmission mediated through liquid nitrogen, and praise the safety of their approach; those who use the open systems refer to the lack of evidence of disease transmission and regard their systems as more consistent and efficient. The purpose of this review is to clarify whether open and closed systems are really open and closed; if closed systems are safe and free of any danger of contamination; if closed systems are equally efficient as open ones for cryopreservation of human embryos and oocytes by considering overall outcome; and finally, if ethical and legal concerns are sound when risks and benefits are considered in a broader sense. On the basis of these answers, implementation of rational measures to lower the theoretical dangerof disease transmission are proposed while maintaining the achievements in cryopreservation that have contributed substantially tothe advancement in assisted reproduction techniques during the past decade.

History

Volume

30

Issue

4

Start Page

325

End Page

333

Number of Pages

9

eISSN

1472-6491

ISSN

1472-6483

Location

United Kingdom

Publisher

Elsevier

Language

en-aus

Peer Reviewed

  • Yes

Open Access

  • No

Era Eligible

  • Yes

Journal

Reproductive biomedicine online.

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