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Nitric oxide directed reprogramming of rat bone marrow derived mesenchymal stem cells into endothelial-like cells via activation of WNT/β-catenin signaling

journal contribution
posted on 18.07.2018, 00:00 by N Bandara, A Kong, P Sivakumaran, G Mitchel, L-X Wang, S Lim, Padraig Strappe
Nitric oxide plays an important role in stem cell differentiation and in endothelial cells it is expressed by endothelial nitric oxide synthase (eNOS) which is located within membrane caveolae through scaffolding with caveolin-1 (CAV-1WT) which inhibits NO production. In this study, we modified rat bone marrow mesenchymal stem cells (rBMSCs) with lentiviral vectors to co-express eNOS and mutant caveolin-1 (CAV-1F92A) to enhance NO generation and investigated endothelial reprogramming.

History

Volume

145

Issue

Suppl.

Start Page

S134

End Page

S135

Number of Pages

2

ISSN

0925-4773

Publisher

Elsevier, Ireland

Additional Rights

Open archive

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

Charles Sturt University

Era Eligible

No

Journal

Mechanisms of Development

Exports

CQUniversity

Categories

Exports