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Mucosal immunization against respiratory bacterial pathogens
journal contribution
posted on 2017-12-06, 00:00 authored by A Foxwell, Jennelle KydJennelle Kyd, A CrippsBacterial respiratory diseases remain a major cause of morbidity and mortality throughout the world. The young and the elderly are particularly susceptible to the pathogens that cause these diseases. Therapeutic approaches remain dependent upon antibiotics contributing to the persistent increases in antibiotic resistance. The main causes of respiratory disease discussed in this review are Mycobacterium tuberculosis, Corynebacterium diphtheriae, Bordatella pertussis, Streptococcus pneumoniae, nontypeable Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa. All these organisms initiate disease af the mucosal surface of the respiratory tract and thus the efficacy of the host's response to infection needs to be optimal at this site. Vaccines available for diseases caused by many of these pathogens have limitations in accessibility or efficacy, highlighting the need for improvements in approaches and products. The most significant challenges in both therapy and prevention of disease induced by bacteria in the respiratory tract remain the development of noninjectable vaccines and delivery systems/immunization regimens that improve mucosal immunity.
History
Volume
2Issue
4Start Page
551End Page
560Number of Pages
10eISSN
1744-8395ISSN
1476-0584Location
United KingdomPublisher
Future DrugsLanguage
en-ausPeer Reviewed
- Yes
Open Access
- No
External Author Affiliations
University of Canberra;Era Eligible
- Yes