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Mucosal immunity in the lung and upper airway

journal contribution
posted on 06.12.2017, 00:00 by Jennelle KydJennelle Kyd, A Foxwell, A Cripps
The mucosal surfaces of the lungs and upper airways are common sites for infection. Extensive studies of the mechanisms associated with immune responses in the respiratory tract have found that understanding the system is challenging and involves many complex interactions to prevent and eliminate infection. Immune protection against diseases transmitted through the respiratory tract requires an understanding of the important aspects associated with beneficial, detrimental or ineffective immune responses. Two critical aspects of an immune response against a pathogen are that of the inductive stage, either induced by vaccination or primary infection, and the effector stage, the ability to recognise, respond to and eliminate the infection without detriment to the host. An immunisation strategy must not only have a measure of the induced antigen specific response, but this response must also be protective.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

19

Start Page

2527

End Page

2533

Number of Pages

7

eISSN

1873-2518

ISSN

0264-410X

Location

United Kingdom

Publisher

Elsevier Ltd

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

University of Canberra;

Era Eligible

No

Journal

Vaccine.

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