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Microbiota and the nitrogen cycle: Implications in the development and progression of CVD and CKD

journal contribution
posted on 10.07.2018, 00:00 by D Briskey, Patrick TuckerPatrick Tucker, DW Johnson, JS Coombes
© 2016 Elsevier Inc. All rights reserved.Chronic kidney disease (CKD) is associated with an increased risk of death from cardiovascular disease (CVD). One factor involved in CVD development is nitric oxide (NO), which acts as a powerful vasodilator. NO is produced via the nitrogen cycle, through the reduction of nitrate to nitrite with the process mainly occurring in the mouth by commensal microbiota. People with CKD have compromised microbiota (dysbiosis) with an increased abundance of potentially pathogenic and pro-inflammatory bacteria capable of producing uremic toxins that contribute to CKD development and reduce enzymatic NO production. However, to date, few studies have comprehensively documented the gut or saliva microbiota in the CKD population or investigated the role of NO in people with CKD. This review will discuss NO pathways that are linked to the progression of CKD and CVD and therapeutic options for targeting these pathways.

History

Volume

57

Start Page

64

End Page

70

Number of Pages

7

eISSN

1089-8611

ISSN

1089-8603

Publisher

Academic Press

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

University of Queensland

Era Eligible

Yes

Journal

Nitric Oxide