Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
journal contribution
posted on 2017-12-06, 00:00 authored by L Macia, A Vieira, K Leach, Dragana StanleyDragana Stanley, S Luong, M Maruya, C McKenzie, A Hijikata, C Wong, J TanDiet and the gut microbiota may underpin numerous human diseases. A major metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from fermentation of dietary fibre. Here we show that diets deficient or low in fibre exacerbate colitis development, while very high intake of dietary fibre or the SCFA acetate protects against colitis.
Funding
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
History
Volume
6Start Page
1End Page
15Number of Pages
15eISSN
2041-1723Location
UKPublisher
Nature Publishing GroupPublisher DOI
Full Text URL
Language
en-ausPeer Reviewed
- Yes
Open Access
- No
External Author Affiliations
CSIRO Animal, Food and Health Sciences; Howard Hughes Medical Institute; Max-Planck-Institute for Heart and Lung Research; Monash University; RIKEN Research Center for Allergy and Immunology Tsurumi; School of Medical and Applied Sciences (2013- ); School of Medicine; TBA Research Institute; Universidade Federal de Minas Gerais;Era Eligible
- Yes
