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Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats

journal contribution
posted on 14.10.2021, 02:15 by Yumei Jiang, Na Zhang, Yawen Zhou, Zhongkai Zhou, Y Bai, Padraig Strappe, Chris Blanchard
Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separately on type 2 diabetic mellitus (T2DM) rats. This work was to explore the effects of administering encapsulated GLS within RS (referred to as EGLS) in the T2DM rats, which were induced by streptozotocin (STZ). The EGLS was orally administered to rats for 28 days. The parameters of glycometabolism and lipometabolism were evaluated, and fecal microbiota composition was investigated. The results showed that EGLS significantly enhanced glycometabolism and lipometabolism parameters in T2DM rats, which might be associate with the enhancement of the glucose and lipid metabolism, insulin secretion, and glycogen synthesis and reduced lipogenesis. Furthermore, the intervention of EGLS also reduced the Proteobacteria community and improved dysfunctional gut microbiota. This study indicated EGLS may be a potential candidate for dietary intervention to modulate diabetes.

Funding

Category 3 - Industry and Other Research Income

History

Volume

30

Issue

5

Start Page

755

End Page

764

Number of Pages

10

eISSN

2092-6456

ISSN

1226-7708

Location

Korea (South)

Publisher

Springer

Language

eng

Peer Reviewed

Yes

Open Access

No

Acceptance Date

27/03/2021

External Author Affiliations

Charles Sturt University; Nanjing Agriculture University, Tianjin University of Science and Technology, China

Era Eligible

Yes

Medium

Electronic-eCollection

Journal

Food Science and Biotechnology