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LDL species heterogeneity in the atherogenic dyslipidemia of polycystic ovary syndrome

journal contribution
posted on 06.12.2017, 00:00 authored by S Doi, J Abbas, Lynne Parkinson, J Chakraborty, A Akanji
One of the important risk factors for coronary heart disease is dyslipidemia. Several lipid abnormalities have been studied in patients with polycystic ovary syndrome (PCOS), but the relationship between PCOS and low-density lipoprotein (LDL) subclass pattern is not clear. A case-control study was designed to look into lipid differences, and LDL size was analyzed by a newly developed polyacrylamide tube gel electrophoresis method. Results indicated that only PCOS status and serum triglyceride levels were independently associated with LDL particle size. The apolipoprotein (Apo)A-I level was higher in PCOS patients with small dense LDL (sdLDL). PCOS seems to result in smaller LDL particle size and higher ApoA-I levels independent of triglyceride levels. After adjusting for triglyceride levels, other traits of insulin resistance syndrome (IRS) were not associated with LDL size phenotype, suggesting that the IRS-related sdLDL is linked most strongly to alterations in triglyceride levels.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

129

Issue

5

Start Page

802

End Page

810

Number of Pages

9

eISSN

1943-7722

ISSN

0002-9173

Location

United States

Publisher

American Society for Clinical Pathology

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Jāmi'at al-Kuwayt; Mubarak Al-Kabeer Teaching Hospital, Kuwait; TBA Research Institute; University of Newcastle;

Era Eligible

Yes

Journal

American journal of clinical pathology.