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LDL species heterogeneity in the atherogenic dyslipidemia of polycystic ovary syndrome
journal contribution
posted on 2017-12-06, 00:00 authored by S Doi, J Abbas, Lynne Parkinson, J Chakraborty, A AkanjiOne of the important risk factors for coronary heart disease is dyslipidemia. Several lipid abnormalities have been studied in patients with polycystic ovary syndrome (PCOS), but the relationship between PCOS and low-density lipoprotein (LDL) subclass pattern is not clear. A case-control study was designed to look into lipid differences, and LDL size was analyzed by a newly developed polyacrylamide tube gel electrophoresis method. Results indicated that only PCOS status and serum triglyceride levels were independently associated with LDL particle size. The apolipoprotein (Apo)A-I level was higher in PCOS patients with small dense LDL (sdLDL). PCOS seems to result in smaller LDL particle size and higher ApoA-I levels independent of triglyceride levels. After adjusting for triglyceride levels, other traits of insulin resistance syndrome (IRS) were not associated with LDL size phenotype, suggesting that the IRS-related sdLDL is linked most strongly to alterations in triglyceride levels.
Funding
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
History
Volume
129Issue
5Start Page
802End Page
810Number of Pages
9eISSN
1943-7722ISSN
0002-9173Location
United StatesPublisher
American Society for Clinical PathologyPublisher DOI
Full Text URL
Language
en-ausPeer Reviewed
- Yes
Open Access
- No
External Author Affiliations
Jāmi'at al-Kuwayt; Mubarak Al-Kabeer Teaching Hospital, Kuwait; TBA Research Institute; University of Newcastle;Era Eligible
- Yes