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Konjac glucomannans attenuate diet-induced fat accumulation on livers and its regulation pathway

journal contribution
posted on 27.02.2020, 00:00 by W Shang, H Li, Padraig Strappe, Z Zhou, C Blanchard
As one typical dietary fiber, Konjac glucomannan (KGM) is applied to investigate its influence on high-fat diet (HFD) induced liver dysbiosis. The current results indicated dietary KGM was associated with a declined accumulation of fat droplets on animal livers with significantly improved serum lipid compositions through a reduced biosynthesis of free fatty acid, ceramides, and oxidized-triacylglycerols, benefiting the attenuation of oxidative levels. This is the first study to reveal that KGM intervention led an increased level of hydrophilic bile acids and a reduced content of hydrophobic ones in feces. The associated lipid regulatory pathways of AMPK, PPAR and fatty acid metabolism were significantly enriched following KGM intervention. It highlights that the activation of the PI3K pathway and modulation of the expression of the adipogenic regulators of LXR and PPARγ might be the key manipulation patterns of KGM on the attenuation of liver dysbiosis induced by HFD. © 2018 Elsevier Ltd

Funding

Other

History

Volume

52

Start Page

258

End Page

265

Number of Pages

8

eISSN

2214-9414

ISSN

1756-4646

Publisher

Elsevier, Nehterlands

Peer Reviewed

Yes

Open Access

No

Acceptance Date

03/11/2018

External Author Affiliations

Charles Sturt University; Tianjin University of Science and Technology, China

Era Eligible

Yes

Journal

Journal of Functional Foods

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