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Kinetics of inflammatory cytokines in the clearance of non-typeable Haemophilus influenzae from the lung
journal contribution
posted on 2017-12-06, 00:00 authored by A Foxwell, Jennelle KydJennelle Kyd, A CrippsLevels of the pro-inflammatory cytokines TNF-x and TNF-y were measured from the time of infection to the time of complete clearance of non-typeable Haemophilus influenzae (NTHi) from the lung in immune and non-immune rats. Mucosal immunization facilitated production of significant levels of TNF-x as early as 30 min post-pulmonary challenge with NTHi in immune animals. Following the peak at 2h, rapid decline of TNF-x levels occurred from the alveolar spaces. Levels of TNF-x in non-immunized animals increased at a slower rate, peaked at a lower concentration and were slower to decline. The significantly larger number of macrophages seen in the immune animals at 1 h after bacterial challenge could partially account for the higher levels of TNF-x. interferon-y was not detected in immune or non-immune rats at any time point before NTHi clearance after pulmonary challenge. Study of the kinetics of TNF-x release demonstrates that immunized animals control the release of pro-inflammatory cytokines more effectively than non-immunized animals for enhanced clearance of bacterial infection from the lungs
Funding
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
History
Volume
76Start Page
556End Page
559Number of Pages
4eISSN
1440-1711ISSN
0818-9641Location
United KingdomPublisher
Nature Publishing GroupPublisher DOI
Full Text URL
Language
en-ausPeer Reviewed
- Yes
Open Access
- No
Era Eligible
- No