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Kinetics of inflammatory cytokines in the clearance of non-typeable Haemophilus influenzae from the lung

journal contribution
posted on 06.12.2017, 00:00 authored by A Foxwell, Jennelle KydJennelle Kyd, A Cripps
Levels of the pro-inflammatory cytokines TNF-x and TNF-y were measured from the time of infection to the time of complete clearance of non-typeable Haemophilus influenzae (NTHi) from the lung in immune and non-immune rats. Mucosal immunization facilitated production of significant levels of TNF-x as early as 30 min post-pulmonary challenge with NTHi in immune animals. Following the peak at 2h, rapid decline of TNF-x levels occurred from the alveolar spaces. Levels of TNF-x in non-immunized animals increased at a slower rate, peaked at a lower concentration and were slower to decline. The significantly larger number of macrophages seen in the immune animals at 1 h after bacterial challenge could partially account for the higher levels of TNF-x. interferon-y was not detected in immune or non-immune rats at any time point before NTHi clearance after pulmonary challenge. Study of the kinetics of TNF-x release demonstrates that immunized animals control the release of pro-inflammatory cytokines more effectively than non-immunized animals for enhanced clearance of bacterial infection from the lungs

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

76

Start Page

556

End Page

559

Number of Pages

4

eISSN

1440-1711

ISSN

0818-9641

Location

United Kingdom

Publisher

Nature Publishing Group

Language

en-aus

Peer Reviewed

Yes

Open Access

No

Era Eligible

No

Journal

Immunology and cell biology.