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Intercellular communication between malaria-infected erythrocytes in the accelerated multidrug resistance phenotype of the Plasmodium falciparum parasite

journal contribution
posted on 04.09.2018, 00:00 by Andrew Taylor-Robinson, OO Omitola
The so-called ARMD (‘accelerated resistance to multidrug’) phenotype of the human malaria parasite Plasmodium falciparum that is prevalent in South East Asia is believed to confer a special hypermutator characteristic upon parasite strains in which it is expressed. Examination of the ARMD phenotype suggests that alternative mechanisms may be responsible for this ability that is unique among strains of P. falciparum parasite worldwide, but over which there is concern that further dissemination may lead to widespread loss of sensitivity to current chemotherapeutic regimens. Therefore, other recently discovered mechanisms that demonstrate potential in contributing to this noted drug resistance phenomenon merit further investigation. One important example, the cell-to-cell communication pathway in P. falciparum-infected erythrocytes, is being examined as a potential target for intervention and forms the subject of this article.

History

Volume

1

Issue

1

Start Page

1

End Page

3

Number of Pages

3

ISSN

1680-0192

Additional Rights

Published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

Federal University of Agriculture, Abeokuta, Nigeria

Era Eligible

Yes

Journal

Journal of Infectious Diseases and Medicine