High intensity interval training favourably affects angiotensinogen mRNA expression and markers of cardiorenal health in a rat model of early-stage chronic kidney disease

The majority of CKD-related complications stem from cardiovascular pathologies such as hypertension. To help reduce cardiovascular complications, aerobic exercise is often prescribed. Emerging evidence suggests high intensity interval training (HIIT) may be more beneficial than traditional aerobic exercise. However, appraisals of varying forms of aerobic exercise, along with descriptions of mechanisms responsible for health-related improvements, are lacking. This study examined the effects of 8 weeks of HIIT (85% VO2max), versus low intensity aerobic exercise (LIT; 45–50% VO2max) and sedentary behaviour (SED), in an animal model of early-stage CKD. Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. Compared to SED,HIIT resulted in increased plasma albumin (̧‘ = 0.001), reduced remnant kidney weight (̧‘ = 0.028), and reduced kidney weight-body weight ratios (̧‘ = 0.045). Compared to LIT, HIIT resulted in reduced Agt mRNA expression (̧‘ = 0.035), reduced plasma LDL (̧‘ = 0.001), triglycerides (̧‘ = 0.029), and total cholesterol (̧‘ = 0.002), increased plasmaalbumin (̧‘ = 0.047), reduced remnant kidney weight (̧‘ = 0.005), and reduced kidney weight-body weight ratios (̧‘ = 0.048). These results suggest HIIT is a more potent regulator of several markers that describe and influence health in CKD.