Generation of diverse neural cell types through direct conversion.pdf (1.15 MB)
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Generation of diverse neural cell types through direct conversion

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journal contribution
posted on 09.02.2022, 00:43 authored by GF Petersen, Padraig Strappe
A characteristic of neurological disorders is the loss of critical populations of cells that the body is unable to replace, thus there has been much interest in identifying methods of generating clinically relevant numbers of cells to replace those that have been damaged or lost. The process of neural direct conversion, in which cells of one lineage are converted into cells of a neural lineage without first inducing pluripotency, shows great potential, with evidence of the generation of a range of functional neural cell types both in vitro and in vivo, through viral and non-viral delivery of exogenous factors, as well as chemical induction methods. Induced neural cells have been proposed as an attractive alternative to neural cells derived from embryonic or induced pluripotent stem cells, with prospective roles in the investigation of neurological disorders, including neurodegenerative disease modelling, drug screening, and cellular replacement for regenerative medicine applications, however further investigations into improving the efficacy and safety of these methods need to be performed before neural direct conversion becomes a clinically viable option. In this review, we describe the generation of diverse neural cell types via direct conversion of somatic cells, with comparison against stem cell-based approaches, as well as discussion of their potential research and clinical applications

History

Volume

8

Issue

2

Start Page

32

End Page

46

Number of Pages

15

eISSN

1948-0210

ISSN

1948-0210

Publisher

Baishideng Publishing Group Co. Limited

Additional Rights

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Peer Reviewed

Yes

Open Access

Yes

Acceptance Date

29/12/2015

External Author Affiliations

Charles Sturt University

Era Eligible

Yes

Journal

World Journal of Stem Cells

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