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Functional differences between M cells and enterocytes in sampling luminal antigens

journal contribution
posted on 06.12.2017, 00:00 by Jennelle KydJennelle Kyd, A Cripps
Oral delivery of agents such as vaccines offers a number of significant advantages over parenteral routes, yet only a small number of oral vaccines are routinely available today. The small intestine contains lymphoid aggregates that are overlaid by M cells. These aggregates are part of the gut-associated lymphoid tissues and are important for determining host responses to particulate antigenic material within the small intestine. Differentiating the receptor requirements fo rM cell uptake and transcytosis of bacterial antigen from the intestine has progressed although the specific signalling mechanisms that initiate antigen uptake and specifically target antigen to these cells is still relatively unknown. Microbial pathogen-associated molecular patterns (PAMPs) are recognised by the innate immune system through pattern recognition receptors (PRRs) either through direct receptor–bacterial ligand or endogenous adaptor–bacterial molecule interactions. PRRs on the surface of M cells that have been identified as important in antigen transcytosis include toll-like receptor-4, platelet-activating factor receptor and 5 1 integrin. A numberof these PRRs are also found on neighbouring enterocytes and therefore the pathways signalled by receptor–ligand binding may differentially trigger different transduction pathways. Elucidation of these signalling pathways may assist in the design of effective oral vaccines that target the gut-associatedl ymphoid tissue.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

26

Start Page

6221

End Page

6224

Number of Pages

4

eISSN

1358-8745

ISSN

0264-410X

Location

United Kingdom

Publisher

Elsevier

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Capricornia Centre for Mucosal Immunology; Griffith University; TBA Research Institute;

Era Eligible

Yes

Journal

Vaccine.

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