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Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D)

journal contribution
posted on 2024-06-17, 02:56 authored by GJ Carroll, G Sharma, A Upadhyay, JA Jazayeri
Objectives: In view of the clinical similarities between polyarticular osteoarthritis (POA) with metacarpophalangeal (MCP) joint involvement and the arthropathy that occurs in hereditary haemochromatosis (HH), it was hypothesized that osteochondral damage in both disorders may be due to localized iron overload. Accordingly, it was predicted that the concentration of ferritin in synovial fluid (SF) would be higher in OA patients with HFE gene mutations than in HFE wild-type (wt) OA patients. The aim of this study was to test this proposition. Methods: Sequential patients with physician-diagnosed OA and, for comparison, diverse inflammatory diseases of the joints, who required diagnostic or therapeutic arthrocentesis, were studied. Participants underwent HFE genotyping. SF samples were assayed for ferritin and also for selected cytokines and matrix metalloproteinases (MMPs). Results: Seventy-three patients with diverse rheumatic disorders were recruited. Of the 29 patients who had knee OA, 15 were wt and 14 were heterozygous for HFE mutations (C282Y or H63D). Mean SF ferritin concentrations in the wt and heterozygous OA groups were 273 and 655 ngmL, respectively (p 0.0146). Conclusions: A predicted difference in SF ferritin concentrations in patients with knee OA was confirmed. Concentrations of ferritin in the SF were found to be two-to threefold higher in knee OA patients with HFE gene mutations compared to wt patients. This finding is consistent with the possibility that, in OA patients with HFE gene mutations, localized iron overload may contribute either directly or indirectly to osteochondral damage, possibly in a similar way to that which occurs in the arthropathy that complicates HH. © 2010 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.

Funding

Category 2 - Other Public Sector Grants Category

History

Volume

39

Issue

5

Start Page

413

End Page

420

Number of Pages

8

eISSN

1502-7732

ISSN

0300-9742

Publisher

Informa UK Limited

Language

en

Peer Reviewed

  • Yes

Open Access

  • No

Acceptance Date

2010-02-04

Era Eligible

  • Yes

Medium

Print

Journal

Scandinavian Journal of Rheumatology

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