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Extracts of common pulses demonstrate potent in vitro anti-adipogenic properties

journal contribution
posted on 10.08.2018, 00:00 by K Reynolds, J Wood, F Wang, Z Zhou, C Blanchard, Padraig Strappe
Pulses are an important food source in many countries and also widely used as feed for livestock. Discovery of novel health benefits in pulses may contribute to improved diet and potential added value to crops. In this study, we examined the ability of extracts from faba bean, field pea and chickpea to inhibit the formation of fat droplets in an in vitro cell culture system that mimics the process of fat cell formation or adipogenesis. Both seed and hull extracts of all three pulses showed an inhibition of adipogenesis and the hull fraction and also contained higher levels of polyphenols compared with the seed extracts. At the molecular level, adipogenic inhibition was associated with a marked reduction in peroxisome proliferatoractivated receptor gamma (PPARG) gene expression. Furthermore, the field pea pulse extract was shown to inhibit pancreatic lipase activity at a similar level to the drug ‘orlistat’, which is commonly used to treat obesity

Funding

Other

History

Volume

51

Issue

6

Start Page

1327

End Page

1337

Number of Pages

11

eISSN

1365-2621

ISSN

0950-5423

Publisher

Blackwell Publishing Inc.

Peer Reviewed

No

Open Access

No

External Author Affiliations

Charles Sturt University; Tamworth Agricultural Institute; Tianjin University of Science and Technology, China;

Era Eligible

Yes

Journal

International Journal of Food Science and Technology

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