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Erythrocyte aggregation and neutrophil function in an aging population

journal contribution
posted on 06.12.2017, 00:00 by R Christy, O Baskurt, Gregory GassGregory Gass, A Gray, S Marshall-Gradisnik
There are limited investigations which have examined the relationship between neutrophil activation and erythrocyte aggregation in older persons. The purpose of the present study was to investigate the relationship between neutrophil activation and erythrocyte aggregation (EA) in an aging population. Twenty-eight male and female subjects were allocated into one of four groups with 7 participants in each group (group 1, 20-29 years; group 2, 30-39 years; group 3, 40-49 years; group 4, 50-59 years). EA was determined using the Myrenne aggregometer. Neutrophil function (respiratory burst and phagocytic activity) was assessed using flow cytometry. EA was found to increase with age. An ANOVA showed a significant (p...0.05) increase for EA in autologous plasma in group 4 compared to groups 1 and 2. An ANOVA and Pearson's correlation showed that phagocytic activity decreased with age. Furthermore, a positive correlation between stimulated phagocytic activity and erythrocyte aggregability at low shear in 3... dextran-70 solution was observed. The current investigation suggests a decrease in neutrophil phagocytic activity with age and EA was increased with age. Additionally, the current study is novel as it suggests a possible relationship between neutrophil phagocytic activity and erythrocyte aggregability.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

56

Issue

2

Start Page

175

End Page

180

Number of Pages

6

eISSN

1423-0003

ISSN

0304-324X

Location

Switzerland

Publisher

Karger

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Akdeniz Üniversitesi; Bond University (Gold Coast, Qld.);

Era Eligible

Yes

Journal

Gerontology

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