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Emergence and persistence of hantavirus in rodent reservoirs : role of glucocorticoid hormone

journal contribution
posted on 06.12.2017, 00:00 authored by A Mahmud-Al-Rafat, Andrew Taylor-Robinson
Rodent-borne hantaviruses have received considerable attention in recent years due to the high mortality rate in humans that their infections cause. Anthropogenic stressors are key factors in the emergence of hantavirus-associated diseases. Urbanization, deforestation, noise pollution, artificial lighting and electromagnetic fields are the most common forms of human impact on the environment. An increased systemic concentration of the immunosuppressive class of steroid hormone glucocorticoid is a frequent consequence of chronic anthropogenic stress. Elevated glucocorticoid levels play a crucial role in modulating immune tolerance of rodents, thereby enabling establishment of the host-pathogen interaction. Glucocorticoids support virus persistence in the reservoir host by activating an organ-specific regulatory response mediated by T regulatory lymphocytes to reduce inflammatory and antiviral responses, principally via production of cytokines interleukin-10 and transforming growth factor-β. In-depth analysis of this mechanism would help to understand how rodents maintain a disease-free condition. This may have implications for a cost-effective intervention strategy against hantavirus and other zoonotic human pathogens.

History

Volume

2

Issue

a9

Start Page

1

End Page

5

Number of Pages

5

ISSN

2090-0392

Location

India

Publisher

Biohelikon

Language

en-aus

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

Khulna University; School of Medical and Applied Sciences (2013- ); TBA Research Institute;

Era Eligible

Yes

Journal

Immunity and diseases.