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Effects of synbiotic consumption on lipid profile: A systematic review and meta-analysis of randomized controlled clinical trials

journal contribution
posted on 02.11.2020, 00:00 authored by A Hadi, E Ghaedi, Saman KhalesiSaman Khalesi, M Pourmasoumi, A Arab
Background and aims: Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive. The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile. Methods: A systematic literature search of online databases PubMed, Scopus, ISI Web of science, Cochrane's library and Google Scholar was conducted up to January 2019. Randomized controlled trials (RCTs) investigating the effects of synbiotics on lipid profile in adults were included. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model. Results: A total of 23 RCTs with 1338 participants were included. Synbiotic consumption resulted in a significant decrease in plasma concentrations of total cholesterol (WMD = − 10.17 mg/dL; 95% CI − 15.74 to − 4.60; p ' 0.001), triglyceride (WMD = − 14.30 mg/dL; 95% CI − 25.32 to − 3.28; p = 0.01), low-density lipoprotein cholesterol (WMD = − 8.32 mg/dL; 95% CI − 13.21 to − 3.43; p ' 0.001), and an increase in plasma high-density lipoprotein cholesterol (WMD = 1.3 mg/dL; 95% CI 0.03 to 2.56; p = 0.04) levels compared to control (placebo supplements/control foods/conventional products). The effects are more pronounced when synbiotics supplements are consumed for ' 8 weeks. Conclusion: Synbiotic supplements may be beneficial to improve lipid profile, especially when they are consumed for ' 8 weeks.

History

Volume

59

Issue

7

Start Page

2857

End Page

2874

Number of Pages

18

eISSN

1436-6215

ISSN

1436-6207

Publisher

Springer

Peer Reviewed

Yes

Open Access

No

Acceptance Date

01/04/2020

External Author Affiliations

Halal Research Centre, Tehran University; Guilan University, Isfahan University, Iran

Author Research Institute

Appleton Institute

Era Eligible

Yes

Journal

European Journal of Nutrition