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Effects of anthropogenic events and viral persistence on rodent reservoirs of hantavirus infection : understanding host-pathogen interactions facilitates novel approaches to intervention strategies

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journal contribution
posted on 06.12.2017, 00:00 by A Mahmud-Al-Rafat, M Sobhani, Andrew Taylor-RobinsonAndrew Taylor-Robinson
Hantaviruses are primarily rodent-borne pathogens which have received considerable attention recently due to their high mortality rates in humans. In order to find the causes of rapid transmission and emergence of hantavirus-associated diseases anthropogenic changes are a priority. These include deforestation, urbanization, noise pollution, light pollution and electromagnetic fields, all of which have been shown to profoundly affect rodent physiology and immunology. Moreover, anthropogenic events promote human-rodent co-habitation and thereby provide a driver to increase rates of transmission and, by extrapolation, levels of infection in humans. Such environmental disruption acts as a chronic stressor to rodents and causes elevated concentrations of glucocorticoids, which are a major class of immunosuppressive hormone. Glucocorticoids are responsible for altering the immune tolerance of rodents, thereby rendering them susceptible to infection. Glucocorticoids induce regulatory T lymphocytes to reduce inflammatory and antiviral responses and to activate regulatory responses, principally through production of the cytokines interleukin-10 and transforming growth factor-β to support viral persistence. In order to develop a low-cost intervention strategy for hantavirus infection consideration should be given to a systemic approach to therapy. This would both aim to achieve a reduction of anthropogenic stressors and to gain a greater understanding of host-pathogen interactions.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

3

Issue

2

Start Page

77

End Page

86

Number of Pages

10

ISSN

2328-4056

Location

USA

Publisher

Science & Education Publishing

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Incepta Vaccine Limited (Bangladesh); Khulna University; School of Medical and Applied Sciences (2013- ); TBA Research Institute;

Era Eligible

Yes

Journal

American journal of infectious diseases and microbiology.