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Dissecting the molecular mechanisms of intestinal bacterial translocation to facilitate definition of its proposed role in systemic sepsis

journal contribution
posted on 06.12.2017, 00:00 by A Hamad, H Yaseen, Andrew Taylor-RobinsonAndrew Taylor-Robinson
Intestinal translocation of bacteria is defined as the ingress of gastrointestinal microflora across the lamina propria to local mesenteric lymph nodes and thence to extranodal sites. Bacterial translocation has been long been considered as a possible direct cause of sepsis when under certain conditions bacteria cross the intestinal barrier, enter the systemic circulation and cause a generalised inflammatory response syndrome. While this is an attractive hypothesis, which finds support from experimental models, evidence from clinical studies is equivocal in confirming that bacterial translocation is the primary cause of sepsis. Moreover, the underlying mechanisms by which gut bacteria gain entry to the systemic circulation are not well defined. This review provides a brief overview of bacterial translocation in the intestine, discusses our current understanding of the role it plays in the development of sepsis syndrome and suggests areas for future research to determine the molecular mechanism(s) involved in the aetiology of disease.

History

Volume

12

Issue

2

Start Page

96

End Page

101

Number of Pages

6

ISSN

1681-6579

Location

Iraq

Publisher

Al-Nahrain University

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Al-Anbar University (Iraq); TBA Research Institute;

Era Eligible

Yes

Journal

Iraqi journal of medical sciences.