The design of mechatronic systems of rail vehicles requires performing verification and validation in the real-time mode. One useful validation instrument is the application of software-in-the-loop, hardware-in-the-loop or processor-in-the-loop simulation approaches. All of these approaches require development of a real-time model of the physical system. In this paper, the investigation of the usage of the model of the locomotive’s bogie test rig created in Gensys multibody software has been performed and the calculation time for each time step has been analysed. The verification of the possibility of the usage of such an approach for real-time simulation has been made by means of a simple data transferring process between Gensys and Simulink through the TCP/IP interface. The limitations and further development issues for the proposed approach have been discussed in this paper.